The various bosses in House of the Dead series are mostly undead creatures, further mutated by the experiments of Doctor Curien into powerful monstrosities. Most are impervious to conventional attacks, with the exception of a tiny weak spot. Each is named after one of the Major Arcana tarot cards (until House of the Dead: Overkill) and given a corresponding Type Number. While all are undead, not all are made from a human base (such as the Lovers and the Tower), hence they take many forms, from plants to snakes to spiders. Most are unintelligent, with the mindset comparable to that of a guard dog, but a select few (such as the Hanged Man, The Magician, and Star) show high levels of thought, being able to converse and taunt their opponents. Some can even remember parts of their lives as humans (the Wheel of Fate, the resurrected form of Curien himself).

House of the Dead 1

These mutations were part of the first experiments which created the mutagen that created the zombies. All of them (save the Magician) served as guards to Curien's laboratory, with Hangedman personally assuring the deaths of anyone else on the grounds. These would form the basis for almost all subsequent Mutations, with Chariot and Hangedman directly serving as the template for Judgment in HotD2.

House of the Dead 2

These mutations were created by Goldman to wreck havoc on the streets of Venice. Thus they were generously deployed throughout the city to sow chaos. Many of them claimed a particular territory for themselves, but were put down one by one by the AMS agents. The Magician personally oversaw the defense of the Goldman Building as it's one-man bouncer. Strength was created and deployed solely as a suicidal gladiator against the AMS, while Judgment, Hierophant, and Tower took over the various parts of the city (the streets, river canals, and sewers respectively).

Goldman demonstrated his ability to produce more of these creatures, and resurrected all of the fallen ones after the defeat of Strength to face the AMS agents again. However, having defeated them once before and learned of their weaknesses, these mutations were once again put down by the AMS. Strength was never revived, it's battle being taken over by The Magician.

House of the Dead 3

House of the Dead 4

House of the Dead 4 Special

House of the Dead: Overkill

Unlike the previous games, Overkill's Bosses aren't named after cards of the Major Arcana.

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