He was the creator of the zombies and the main antagonist of the live action movie House of the Dead.
He is portrayed by David Palffy.
Castillo was a Spanish Catholic priest and a criminal banished from his home country of Spain and put on death row for conducting unusual experiments that they say "are not of God", until he made the serum of immortality to live forever. Castillo was banished from Spain (though it is hinted he escaped by choice). Castillo murdered the captain of the ship he stowed up and its crew. He eventually landed on the island, killed the natives and he continued his experiments for centuries after he was first hung by his captors on the island, but didn't die. Castillo and his zombies murdered anyone who came to the island. He used the dead appendages of the victims' bodies to put on himself so he can continue moving faster while his zombies became slower and eventually die (for good) while he lives (implying that his serum of immortality had some flaws).
In the movie, Alicia and the others fight off his zombies and eventually fight him. Alicia gets into a sword duel with Castillo and he stabs her in the heart. Rudy decapitates Castillo, thinking the fight is over, but Castillo is still alive and his headless body begins to strangle Rudy. Alicia, who is barely alive, crushes the Castillo's head under her feet, finally stopping him. She then seems to die after saying, "Game over fucker!" in a final scoff towards Castillo. It's unknown how long Castillo lived and how many times he cheated death. Alicia finally kills Castillo ends his immortal life for good. However, Rudy takes Castillo's research which causes further gruesome events in the future.
Dr. Curien carries on his work by taking his research and the serum and this leads to the events of the second House of the Dead film which is based on the House of the Dead game series.
- "I've been waiting for you for a long time."
- "I just want your flesh."