The Curien Mansion is the location where the events of the first House of the Dead game took place, also serving as the game's namesake. As the name indicates, the mansion was the home of Dr. Roy Curien and his son, Daniel.
As Curien was born of a noble family, the mansion he lived in was originally built in medieval times. While it appeared that the mansion was showing its age as it was starting to fall apart, the house had been upgraded with modern technology as it housed a DBR Research Facility within its walls, where Curien served as its research director.
The mansion would be long remembered as the location of the "Curien Mansion incident" or "1998 Curien Case", when Curien unleashed his experiments upon his staff in an attempt to destroy mankind. His ambitions were put to an end by AMS agents Thomas Rogan and G. During the ordeal, Curien met his demise at the hands of his ultimate creation, The Magician, who in turn was destroyed by the agents.
- In the home versions of The House of the Dead 2, an extended opening sequence shows the mansion as part of a flashback of the previous game.
- In the spin-off game Zombie Revenge, the mansion appears as its own stage, called "The House of the Dead." While its outside appearance is a faithful representation, the interior sections are different. No mention of Curien is made, and the mansion serves as ZED's base of operations.
- The mansion was featured as a court in Sega Superstars Tennis. The House of the Dead name is not used, with the series instead referred to as "Curien Mansion", as The House of the Dead series is banned in Germany.
- The Curien mansion was featured again in Sonic & Sega All Stars Racing, with three race tracks taking place throughout it. The series is once again referred to as "Curien Mansion."