Increasing wars and famines, diseases of unknown origin, increasingly frequent natural disasters. Don't you find it odd? A bit coincidental? Has anyone even noticed? Must we simply sit and wait for it all to end?Caleb Goldman[src]
Despair is the fourth chapter of The House of the Dead 4.
In his office, Caleb Goldman notes the increasing frequencies of wars, diseases, and natural disasters, wondering if humans must "simply sit and wait for [the world] to end".
After their battle with the Empress in the subway system, AMS agents James Taylor and Kate Green enter an underground shopping district. Kate wonders if there are any survivors; James is hopeful that they evacuated. The agents fight through hordes of creatures to the surface of a city.
Suddenly, they are waylaid by Temperance, an obese giant who is resistant to gunfire. The agents retreat to a clock tower and climb to the top, in the process defeating more creatures. Temperance attacks them a final time, but they use a lever to drop a giant clock on the behemoth's head, killing it.
James and Kate continue to the roof, and to their shock find the city in ruins.