(Sega AM1's universe)
Earth has evolved in a way so that it naturally regulates the population of any given species. Humans were once subject to this system, regardless of whether or not they knew it. Pandora's Box is opening.
Hope (希望 kibō ) is the sixth and final chapter of The House of the Dead 4.
In his office, Caleb Goldman remarks that Earth has "evolved" to where it can regulate any given species, and that humanity was once subject to this. Stating that "Pandora's box is opening", he stands up from his desk and grins as AMS agents James Taylor and Gary Stewart confront him, revealing this to be a flashback to the year 2000.
Back in present-day 2003, James and partner Kate Green infiltrate Goldman's headquarters to stop the launch of nuclear missiles. They take an elevator to the 49th floor, which has Japanese decor. When there are only five minutes remaining, Kate helps James climb a flight of stairs, urging him not to give up hope. Using the computer concealed within Goldman's desk, Kate deactivates the nuclear missiles with 30 seconds to spare.
The computer monitor shifts to a video message featuring Goldman. He congratulates the agents and reveals that he did not intend to destroy the world, but merely revert humanity to its "natural state". However, he says that he cannot do anything as Pandora's Box has been opened, although still implies the agents can prevent disaster if they made it this far.
The building shakes as the World, an insectoid creature and the successor to Emperor, emerges from the building courtyard. James and Kate battle the World, which continues to grow and evolve despite their efforts. Realizing this once they start fighting its third form, James sets his PDA to self-destruct and -- telling Kate not to give up hope -- sacrifices himself, obliterating the monster in the process. Shaken and distraught, Kate leaves Goldman's premises.
Depending on the player's performance, one of four endings will play after the credits. The words "The story continues in House of the Dead 3 [sic]" appear afterwards.
- Standard ending: The view returns to the computer in Goldman's office, continuing the late head's pre-recorded message. Goldman gives a final statement as he walks away: "Ah yes, there is one thing I forgot. The human race has not been eliminated. Travel north... hope is such a splendid thing."
- Bad ending: It is the same as the above ending, except when Goldman mentions hope, he takes off his glasses and the camera zooms on his face. His eyes are glowing red, and his face is pale.
- G ending: Accomplished If an "A" average is maintained and an "S" is earned in Chapter 1. AMS agent G appears in front of the smoking crater where James destroyed the World. He tells James to rest, vowing to fight the threat back to its source. As G walks out, the camera pans on Goldman's building before it cuts to black.
- Thornheart ending: Accomplished if an "A" average is maintained with at least one "S" in any Chapter other than the first. A mysterious and unidentified man (previously seen in one of The House of the Dead III's endings) sits at a desk in the corner of an office, stating: "Goldman, you are soft. These wretched humans have no need of hope. Soon, the true end shall begin. ...There is more than one Pandora's Box."
- Like in The House of the Dead 2's sixth chapter, at least one Eric appears inside the elevator.
- The car that James and Kate drove to the Headquarters in the previous chapter is nowhere to be found.