The Information Systems Department is a location within the EFI Research Facility, comprised of east and west wings, as well as a level in The House of the Dead III. Depending on the player's decisions, they will take either the east or west wing.
Upon reaching the Information Systems Department, Lisa Rogan exits the elevator and, despite G's deterrence, runs into laser security systems as the building closes all shutters to stop "unauthorized personnel" from proceeding. Death returns and manages to halt one of the doors from closing.
Death's pursuit of Lisa and G continues as they fend off mutants along their way out and they end up on the other side of the Department, finally defeating Death as they reach the elevator.
Lisa eventually apologizes to G for being stubborn, saying that she should have reacted faster, to which he tells her to "not sweat it".