The following is a comprehensive list of all creaturesin The House of the Dead III. Serving as the main enemies, these creatures were the result of human genome experiments within the EFI Research Facility, as well as some returning from past installments. After the collapse of civilization in 2019, AMS agents investigated the facility and battled the creatures within.
A shirtless bald creature with glowing red eyes and blue pants.
A creature in brown ragged pants with an exposed part of his chest.
A creature with dark circles around his eyes and dark speckles on his body.
A creature in a blue plaid shirt with pockets and blue cargo pants.
A large shirtless creature whose fat belly can withstand multiple bullets. Another variant exists with deep gray mottled skin, a different face, and higher endurance.
A shirtless muscular creature; attacks by swinging a steel frame or punching.
A muscular creature in a military uniform whose behavior is identical to Azteca I.
Believed to be created from a former researcher in the EFI Research Facility. He wields four scalpels in each hand, which he can either throw or slash with at close range. He either appears dressed as a surgeon (left), or in an orange uniform with goggles (right). The orange variant lacks vocals when damaged or killed.
A red dripping creature that crawls on walls and ceilings.
A bandaged small creature with an impressive jumping ability who uses a fluorescent lamp or umbrella as a weapon.
A creature who dual-wields axes, blocking gunfire. He appears and behaves similarly to Johnny zombies from The House of the Dead 2.
A small agile creature with a maniacal hyena laugh, who wields electrical cords connected to the small power box hanging from his neck
A rare creature who only appears once in one of the EFI Genome Ward versions. He behaves identical to the "Mark" series of creatures. According to the Japanese official guide, this creature is actually a gag character of sorts, while his look is directly based on an Sega of America employee's party costume and makeup.
An elite Rogan Commando who was killed during "Chapter 0". He serves as a miniboss much later in the final chapter and can take far more damage. Interestingly enough, unlike the other creatures in the game he can talk, though it appears that he just says random phrases he once said when he was alive like "We are humanity's last hope!" and "That's for my buddies!"
A muscular creature wielding a buzzsaw that deflects bullets.
A creature-plant hybrid; attacks by swinging his vine-like arms.
Vultures often seen around corpses. Often attack in small groups.