Meat Katie is a grotesque, mutated butcher woman with a cow skull and udder attached to her body, resembling a minotaur. She uses a giant meat cleaver in battle. It is unclear how she is mutated into this monstrous form and why she covers her head with a cow skull. She must have been combined with the genes of a cow, explaining why her udder is the source of her weakness.
Katie is confronted by Varla Guns and Candi Stryper in the heart of the meat plant. Even though the girls managed to kill her by multiple gun shots forcing her to fall backwards into a meat grinder and died with a moo in pain but when she fell back her giant cleaver falls out of her grasp and gets wedged on the scaffolding, later ended up severing Candi's lower right arm when it falls down, killing her as a result by exsanguination.
- Meat Katie is the only boss in the series whose actions have a drastic impact on the story (after getting killed, her cleaver ends up on the scaffolding and cuts off Candi's arm slowly killing her). She's also the second boss even after being defeated to successfully kill a protagonist (the first is Death with Dan Taylor).