As it is one the most iconic arcade light gun franchises, The House of the Dead has been referenced multiple times in popular culture.
Film - Animated
- Two references to the original House of the Dead appear in the 2012 animated Walt Disney Studios film Wreck-It Ralph, which centers on arcade gaming and has several references to arcade franchises.
- Cyril, a creature, also makes cameo appearances in Wreck-It Ralph and its sequel Ralph Breaks the Internet. In the original film, Cyril appears at a support group session for video game villains, and tells the titular character to not let his "bad guy" label stop him from loving himself.
- An upright version of the original House of the Dead arcade cabinet appears in several scenes.