Tragedy is the first chapter in The House of the Dead.
On December 20, 1998, AMS agents Thomas Rogan and G drive to the mansion of genetic engineer Dr. Curien, where a special operatives team and DBR Corporation researchers have been reported missing. Prior to their mission, the agents received a distressed phone message from Sophie Richards, Rogan's fiancée and an employee of Curien, before losing contact with her.
Rogan and G arrive at the Curien Mansion just as a humanoid creature kills a researcher. Before dying, the researcher gives the agents a group photo of the other survivors who are still inside the mansion.
The agents encounter Sophie feigning death near a water fountain. As she reunites with them, a winged creature flies her back to the mansion. Rogan and G encounter her again inside the mansion, but an armored creature named Chariot ambushes and attacks her.
After the agents kill Chariot, Sophie urges them to stop Curien before something "terrible" happens. She seemingly dies.
- The House of the Dead Sega Saturn manual, pg. 3
- Sega AM1 (4 March 1997). The House of the Dead. Arcade, Sega Saturn, PC. Level/area: Attract mode. Sophie Richards: Help... Everyone's getting killed...